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Post-doctoral work


  1. Shyam, R.*, Ogando, D.G., Bonanno, J.A. Mitochondrial ROS in Slc4a11 KO Corneal Endothelial Cells Lead to ER Stress. Front. Cell Dev. Biol., 26 April 2022.  * Corresponding author

  2. Shyam, R.*, Ogando, D.G., Kim, E.T., Murugan, S., Choi, M., Bonanno, J.A. Rescue of the CHED Mouse Model by AAV-mediated Slc4a11 Replacement. Ophthalmology Science, 2022. March 2022                           * Corresponding author

  3. Bonanno, J.A., Shyam, R., Choi, M., Ogando, D.G. The H+ Transporter SLC4A11: Roles in Metabolism, Oxidative Stress and Mitochondrial Uncoupling. Cells, 2022. PMID: 35053313.

  4. Shyam, R.*, Ogando, D.G., Choi, M., Liton, P.B., Bonanno, J.A. Mitochondrial ROS  Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy. Investigative Ophthalmology and Visual Sciences, 2021.PMID: 34533563    * Corresponding author

  5.  Ogando, D.G., Shyam, R., Kim, E.T., Wang, YC, Liu, C.Y., Bonanno, J.A. Inducible Slc4a11 knockout triggers corneal edema through perturbation of corneal endothelial pump. Investigative Ophthalmology and Visual Sciences, 2021. PMID: 34190974

  6. Li, S., Shyam, R., Ogando, D.G., Bonanno, J.A. Bicarbonate activates glycolysis and lactate production in corneal endothelial cells by increased pHi. Experimental Eye Research, 2020. PMID: 32818510

  7. Ogando, D.G., Choi, M., Shyam, R., Li, S., Bonanno, J.A. Ammonia sensitive SLC4A11 mitochondrial uncoupling reduces glutamine induced oxidative stress. Redox Biology, 2019. PMID: 31254733


Graduate school work


  1. Shyam, R., Gorusupudi, A., Nelson, K., Horvath, M.P, Bernstein, P.S. RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in vertebrates. Proceedings of the National Academy of Sciences, 2017. PMID: 28874556

  2. Shyam, R., Vachali, P.P., Nelson, K., Gorusupudi, A., and Bernstein, P.S. All three Class B Scavenger receptor proteins function as carotenoid transporters for all three macular carotenoids in the primate eye. Archives of Biochemistry and Biophysics, 2017. PMID: 28947101

  3. Gorusupudi, A.*, Shyam, R.*, Li, B., Vachali, P.P., Subhani, Y., Nelson, K., Bernstein, P.S. Developmentally regulated production of meso-zeaxanthin in chicken retina and retinal pigment epithelium/choroid. Investigative Ophthalmology and Visual Sciences, 2016. PMID: 27082300                (* - Equal contribution)

  4. Bernstein, P.S, Li, B., Vachali, P.P., Gorusupudi, A., Shyam, R., Hendriksen, B., and Nolan, J. Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science  underlying carotenoid-based nutritional interventions against ocular disease. Progress in Retinal Eye Research, 2015. PMID: 26541886

Lab technician work

  1. Qiu, Y., Shen, X., Shyam, R., Yue, B.Y.J.T. and Ying, H. Cellular processing of myocilin. PLoS One, 2014. PMID: 24732711

  2. Turturro, S., Shen, X., Shyam, R., Yue, B.Y.J.T., and Ying, H. Effects of mutations and deletions in the human optineurin gene. Springer Plus, 2014. PMID: 24683533

  3. Shen, X., Ying, H., Park, J-S., Qiu, Y., Shyam, R., Chi, Z-L., Iwata, T., and Yue, B.Y.J.T. Processing of optineurin in neuronal Cells. Journal of Biological Chemistry, 2011. PMID: 21059646

  4. Shyam, R., Shen, X., Yue, B.Y.J.T., and Wentz-Hunter, K. K. Wnt gene expression in human trabecular meshwork cells. Molecular Vision, 2010. PMID: 20111673

  5. Koga, T., Shen, X., Park, J-S., Qiu, Y., Park, B-C., Shyam, R., and Yue, B.Y.J.T.  Differential effects of myocilin and optineurin, two glaucoma genes, on neurite outgrowth. American Journal of Pathology, 2010. PMID: 24683533

  6. Park, B-C., Ying, H., Park, -S., Shen, X., Qiu. Y, Shyam, R., and Yue, B.Y.J.T. Impairment of protein trafficking upon overexpression and mutation of optineurin. PLoS One, 2010. PMID: 20634958

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