Publications
Post-doctoral work
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Shyam, R.*, Ogando, D.G., Bonanno, J.A. Mitochondrial ROS in Slc4a11 KO Corneal Endothelial Cells Lead to ER Stress. Front. Cell Dev. Biol., 26 April 2022. https://doi.org/10.3389/fcell.2022.878395 * Corresponding author
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Shyam, R.*, Ogando, D.G., Kim, E.T., Murugan, S., Choi, M., Bonanno, J.A. Rescue of the CHED Mouse Model by AAV-mediated Slc4a11 Replacement. Ophthalmology Science, 2022. March 2022 https://doi.org/10.1016/j.xops.2021.100084 * Corresponding author
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Bonanno, J.A., Shyam, R., Choi, M., Ogando, D.G. The H+ Transporter SLC4A11: Roles in Metabolism, Oxidative Stress and Mitochondrial Uncoupling. Cells, 2022. PMID: 35053313.
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Shyam, R.*, Ogando, D.G., Choi, M., Liton, P.B., Bonanno, J.A. Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy. Investigative Ophthalmology and Visual Sciences, 2021.PMID: 34533563 * Corresponding author
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Ogando, D.G., Shyam, R., Kim, E.T., Wang, YC, Liu, C.Y., Bonanno, J.A. Inducible Slc4a11 knockout triggers corneal edema through perturbation of corneal endothelial pump. Investigative Ophthalmology and Visual Sciences, 2021. PMID: 34190974
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Li, S., Shyam, R., Ogando, D.G., Bonanno, J.A. Bicarbonate activates glycolysis and lactate production in corneal endothelial cells by increased pHi. Experimental Eye Research, 2020. PMID: 32818510
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Ogando, D.G., Choi, M., Shyam, R., Li, S., Bonanno, J.A. Ammonia sensitive SLC4A11 mitochondrial uncoupling reduces glutamine induced oxidative stress. Redox Biology, 2019. PMID: 31254733
Graduate school work
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Shyam, R., Gorusupudi, A., Nelson, K., Horvath, M.P, Bernstein, P.S. RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in vertebrates. Proceedings of the National Academy of Sciences, 2017. PMID: 28874556
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Shyam, R., Vachali, P.P., Nelson, K., Gorusupudi, A., and Bernstein, P.S. All three Class B Scavenger receptor proteins function as carotenoid transporters for all three macular carotenoids in the primate eye. Archives of Biochemistry and Biophysics, 2017. PMID: 28947101
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Gorusupudi, A.*, Shyam, R.*, Li, B., Vachali, P.P., Subhani, Y., Nelson, K., Bernstein, P.S. Developmentally regulated production of meso-zeaxanthin in chicken retina and retinal pigment epithelium/choroid. Investigative Ophthalmology and Visual Sciences, 2016. PMID: 27082300 (* - Equal contribution)
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Bernstein, P.S, Li, B., Vachali, P.P., Gorusupudi, A., Shyam, R., Hendriksen, B., and Nolan, J. Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease. Progress in Retinal Eye Research, 2015. PMID: 26541886
Lab technician work
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Qiu, Y., Shen, X., Shyam, R., Yue, B.Y.J.T. and Ying, H. Cellular processing of myocilin. PLoS One, 2014. PMID: 24732711
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Turturro, S., Shen, X., Shyam, R., Yue, B.Y.J.T., and Ying, H. Effects of mutations and deletions in the human optineurin gene. Springer Plus, 2014. PMID: 24683533
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Shen, X., Ying, H., Park, J-S., Qiu, Y., Shyam, R., Chi, Z-L., Iwata, T., and Yue, B.Y.J.T. Processing of optineurin in neuronal Cells. Journal of Biological Chemistry, 2011. PMID: 21059646
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Shyam, R., Shen, X., Yue, B.Y.J.T., and Wentz-Hunter, K. K. Wnt gene expression in human trabecular meshwork cells. Molecular Vision, 2010. PMID: 20111673
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Koga, T., Shen, X., Park, J-S., Qiu, Y., Park, B-C., Shyam, R., and Yue, B.Y.J.T. Differential effects of myocilin and optineurin, two glaucoma genes, on neurite outgrowth. American Journal of Pathology, 2010. PMID: 24683533
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Park, B-C., Ying, H., Park, -S., Shen, X., Qiu. Y, Shyam, R., and Yue, B.Y.J.T. Impairment of protein trafficking upon overexpression and mutation of optineurin. PLoS One, 2010. PMID: 20634958